Synthesis and Characterization of Transition Metal Complexes along with their Antibacterial Activities

Abstract

Macrocyclic ligands are polydentate ligands containing donor atoms either incorporated or attached to cyclic backbone and showed significance in various biological studies. Tetraaza macrocyclic complexes of transition metals, Ni(II), Cu(II), Fe(III), and Mn(II) were synthesized in methanolic media using template method. These complexes were non-hygroscopic and consist of crystalline solids. Structural identification of these complexes was done using analytical techniques UV-Vis and IR Spectroscopy. The antibacterial activities of macrocyclic complexes (1-6) were screened against both Gram-negative bacteria (Escherichia coli and Vibrio cholerae) and Gram-positive bacteria (Bacillus subtilis and Staphylococcus aureus). In the present study we have reported that these synthesized complexes showed slight antibacterial activity except macrocyclic complex (6) which showed moderate antibacterial activity.