Effect of Sterilized Ag Nano Particles using -irradiation on human blood (in Vitro) Biocompatibility

Abstract

In this study we tested gamma irradiation method of sterilization which traditionally used in medical device industry on silver nano particles and monitored the effect on biocompatibility and other particles, here we investigate the effect of three gamma radiation equivalent dose (5, 10, 15) Sv on the biocompatibility of nano silver with particle size distribution (20 – 40) nm on human blood Exposing nano silver colloid samples to gamma irradiation caused increase in platelet aggregation within ( in vitro) method compared to theor treated counterparts. We also observe positive tendency of sterilized silver nano particles to cause platelet aggregation, sensitive in vitro indication of thrombogencity, also positive effect on other blood parameters such as HCT.